Anti-Human c-Myc Purified

The 9E10 monoclonal antibody specifically reacts with the human c-Myc p67 molecule, a proto-oncogene from the Myc family, which is important in transformation, proliferation, and differentiation. This gene is expressed during embryonic development, in some adult tissues, and is amplified in some tumors. Inside the cell, the gene is localized in the nucleus or cytoplasm. C-Myc is characterized by a Leucine zipper, a basic region, and a helix-loop-helix, which allow the formation of a heterodimer Myc-Max that binds to DNA, and activates the transcription.

The 9E10 antibody recognizes the human c-Myc and can be used for Myc-tagged protein detection. It was obtained by using synthetic peptide similar to the terminal domain of human c-Myc as an immunogen.

The product should be stored undiluted at 4C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.