Anti-Mouse CD8a BG Violet 450

The 2.43 monoclonal antibody specifically reacts with mouse CD8 antigen. CD8a (the alpha chains) form heterodimers with CD8b (the beta chains) or homodimers (alpha-alpha), which occur as receptors on the surface of the majority of thymocytes. A subpopulation of mature T lymphocytes expresses the CD8 alpha beta (alpha beta TCR T cells), and a subpopulation of intestinal intraepithelial lymphocytes and dendritic cells express CD8a without CD8b.

CD8 interacts with the mouse major histocompatibility complex class I (MHC class I) molecules on antigen-presenting cells or epithelial cells.

BG Violet 450 conjugate is an alternative to the Pacific Blue, eFluor 450, or BD Horizon V450 dyes. It is excited by the violet (405 nm) laser, with a peak emission of 450nm.

Determined by its ability to chemoattract IL-2 activated T cells using a concentration range of 0.1-10.0 ng/ml.
Assay #2: Determined by its ability to chemoattract CXCR3 transfected/HEK293 cells using a con

Immunology, Angiogenesis, Neurosciences, Inflammation, Proliferation and Cell Cycle, Chemotaxis