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Anti-Mouse CD28 Purified

Anti-Mouse CD28 Purified

ArtNr	10312-20-100
Hersteller	BioGems
Menge	100 ug
Kategorie	Neuroscience Neural Lineage Markers Aging & Neurological Disorders Antibodies Flow Cytometry Immunoprecipitation Primary Antibodies
Typ	Antibody
Format	Purified
Applikationen	FC, IP
Clon	37.51
Specific against	Mouse (Murine, Mus musculus)
Host	Hamster - Armenian
Isotype	IgG
Citations	Nandi, D., Gross, J. A., & Allison, J. P. (1994). CD28-mediated costimulation is necessary for optimal proliferation of murine NK cells. The Journal of Immunology, 152(7), 3361-3369. Gross, J. A., Callas, E. L. E. N. I., & Allison, J. P. (1992). Identification and distribution of the costimulatory receptor CD28 in the mouse. The Journal of Immunology, 149(2), 380-388. Grossi, J. A., Raulet, D. H., & Allison, J. P. (1992). CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones.Nature, 356, 607-9. Nishio, M., Spielman, J., Lee, R. K., Nelson, D. L., & Podack, E. R. (1996). CD80 (B7. 1) and CD54 (intracellular adhesion molecule-1) induce target cell susceptibility to promiscuous cytotoxic T cell lysis. The Journal of Immunology,157(10), 4347-4353.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Lieferbar
Description	The 37.51 monoclonal antibody specifically reacts with mouse CD28 molecule, a 45 kDa homodimer. It is expressed on most thymocytes, at low density on most of the CD4+ and CD8+ peripheral T lymphocytes, and on the natural killer cells. It is additionally found on activated splenocytes, mast cells, and thymocytes. CD 28 is a costimulator of T lymphocytes and a ligand for CD80 (B7-1), and CD86 (B7-2). The CD28 signaling stimulates the expression of IL-2 and IL-2 receptor and the cytotoxicity of CD3-activated T lymphocytes. The 37.51 antibody stimulates the proliferation of T lymphocytes and natural killer cells and their respective cytokine production.
Storage Temperature	4C
Formulation	Phosphate-buffered aqueous solution, ≤ 0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Preperation	The product should be stored undiluted at 4C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Research Interest	Adaptive Immunity
Format	Purified

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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10312-20-100-datasheet.pdf

10312-20-100-safety-datasheet.pdf