Anti-Mouse IL-13 SAFIRE Purified

ArtNr	83512-25-500
Hersteller	BioGems
Menge	500 ug
Kategorie	Neuroscience Neuroinflammation Metabolism Diabetes Glucose Homeostasis Antibodies Cell Biology Cell Culture Cytokines Primary Antibodies
Typ	Antibody
Format	SAFIRE (Functional)
Clon	1316H
Specific against	Mouse (Murine, Mus musculus)
Host	Rat
Isotype	IgG1 Kappa
Citations	Sasaki, K., Pardee, A. D., Okada, H., & Storkus, W. J. (2008). IL-4 inhibits VLA-4 expression on Tc1 cells resulting in poor tumor infiltration and reduced therapy benefit. European journal of immunology, 38(10), 2865-2873. Park, S. H., Chen, W. C., Esmaeil, N., Lucas, B., Marsh, L. M., Reibman, J., & Grunig, G. (2014). Interleukin 13-"and interleukin 17A-"induced pulmonary hypertension phenotype due to inhalation of antigen and fine particles from air pollution. Pulmonary circulation, 4(4), 654. Blum, L. K., Mohanan, S., Fabre, M. V., Yafawi, R. E., & Appleton, J. A. (2013). Intestinal infection with Trichinella spiralis induces distinct, regional immune responses. Veterinary parasitology, 194(2), 101-105.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Lieferbar
Description	The 1316H monoclonal antibody binds to mouse IL-13. IL-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells, and also by mast cells and NK cells. Targeted deletion of IL-13 in mice resulted in impaired Th2 cell development and indicated an important role for IL-13 in the expulsion of gastrointestinal parasites. IL-13 exerts anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as IL-1β, TNF-α, IL-6 and IL-8. IL-13 has also been shown to enhance B cell proliferation and to induce isotype switching, resulting in increased production of IgE. Blocking of IL-13 activity inhibits the pathophysiology of asthma. The 1316H antibody is reported to be a neutralizing antibody.
Storage Temperature	4C
Formulation	Phosphate-buffered aqueous solution, ph7.2.
Preperation	The product should be stored undiluted at 4C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography.
Research Interest	Adaptive Immunity
Format	SAFIRE (Functional)

Hinweis: Die dargestellten Informationen und Dokumente (Bedienungsanleitung, Produktdatenblatt, Sicherheitsdatenblatt und Analysezertifikat) entsprechen unserem letzten Update und sollten lediglich der Orientierung dienen. Wir übernehmen keine Garantie für die Aktualität. Für spezifische Anforderungen bitten wir Sie, uns eine Anfrage zu stellen.

Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Arbeitsanleitung (Data Sheet) anfordern

83512-25-500-datasheet.pdf

83512-25-500-safety-datasheet.pdf