CDK4 Polyclonal Antibody

Hersteller Biomatik
Kategorie Produkte / Antibody / Research Area / Oncology / Bladder Cancer / Head and Neck Cancers
Typ Antibody Polyclonal
Specific against Human
Applikationen IHC, ELISA
Menge 100ug
Host Rabbit
ArtNr BM-CAC07120-100ug
Eclass 6.1 32160702
Eclass 9.0 32160702
Lieferbar
Immunogen
Recombinant human Cyclin-dependent kinase 4 protein (2-303AA)
Conjugate
Unconjugated
Alternative Names
Cell division protein kinase 4, PSK-J3, CDK4
UniProt ID
P11802
Purification
Caprylic Acid Ammonium Sulfate Precipitation Purified
Storage Instructions
Aliquot and store at -20C. Minimize freezing and thawing.
Expiry Date
1 year
Shipping Condition
Blue ice
Comment
Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
Restriction
For research use only. Not for diagnostic procedures.
Menge: 100ug
Lieferbar: In stock
Listenpreis: 331,88 €
Preis: 331,88 €
lieferbar

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