|
Hersteller |
Biomatik |
|
Kategorie |
|
|
Typ |
Antibody Polyclonal |
|
Specific against |
Human |
|
Menge |
50ug |
|
Host |
Rabbit |
|
ArtNr |
BM-CAC08328-50ug |
|
Eclass 6.1 |
32160702 |
|
Eclass 9.0 |
32160702 |
|
Lieferbar |
 |
| Clonality |
Polyclonal |
| Isotype info |
Recombinant human Thiopurine S-methyltransferase protein (4-244AA) |
| Immunogen |
ELISA, WB, IHC; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200 |
| Conjugation |
Unconjugated |
| Alternative Names |
Thiopurine methyltransferase |
| UniProt ID |
P51580 |
| Purification |
>95%, Protein G purified |
| Storage |
-20°C |
| Expiry Date |
1 year |
| Shipping Condition |
Ice packs |
| Comments |
Conjugation service and the corresponding secondary antibody are available. |
| Technical Notes |
TPMT is an enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals. A pseudogene for this locus is located on chromosome 18q. |
| Restriction |
For research use only. Not for diagnostic procedures. |
