Hersteller |
Biomatik |
Kategorie |
Produkte / Antibody |
Typ |
Antibody Polyclonal |
Specific against |
Human |
Menge |
50ug |
Host |
Rabbit |
ArtNr |
BM-CAC08328-50ug |
Eclass 6.1 |
32160702 |
Eclass 9.0 |
32160702 |
Lieferbar |
|
Clonality |
Polyclonal |
Isotype info |
Recombinant human Thiopurine S-methyltransferase protein (4-244AA) |
Immunogen |
ELISA, WB, IHC; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200 |
Conjugation |
Unconjugated |
Alternative Names |
Thiopurine methyltransferase |
UniProt ID |
P51580 |
Purification |
>95%, Protein G purified |
Storage |
-20°C |
Expiry Date |
1 year |
Shipping Condition |
Ice packs |
Comments |
Conjugation service and the corresponding secondary antibody are available. |
Technical Notes |
TPMT is an enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals. A pseudogene for this locus is located on chromosome 18q. |
Restriction |
For research use only. Not for diagnostic procedures. |