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GRHL3 Polyclonal Antibody

ArtNr BM-CAC08150-50ug
Hersteller Biomatik
Menge 50 UG
Kategorie
Typ Antibody Polyclonal
Applikationen WB, IF, ELISA
Specific against Human (Homo sapiens), Mouse (Murine, Mus musculus)
Host Rabbit
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Alias Grainyhead-like protein 3 homolog,Sister of mammalian grainyhead,Transcription factor CP2-like 4,GRHL3
Lieferbar
Manufacturer - Conjugate / Tag
Unconjugated. Conjugated antibodies are available (Biotin, FITC and HRP), please inquire.
Shipping Temperature
Blue ice
Storage Conditions
Aliquot and store at -20°C. Minimize freezing and thawing.
Restrictions
For research use only. Not for diagnostic procedures.
Expiration
1 year
Purification
Protein G purified, >95%
Comments
Transcription factor playing important roles in primary neurulation and in the differentiation of stratified epithelia of both ectodermal and endodermal origin (By similarity). Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' acting as an activator and repressor on distinct target genes (PubMed:21081122, PubMed:25347468). xhibits functional redundancy with GRHL2 in epidermal morphogenetic events and epidermal wound repair (By similarity). Exhibits functional redundancy with GRHL2 in epidermal morphogenetic events and epidermal wound repair but is essential to form the epidermal barrier with TGM3 as critical direct target gene among others. Despite being dispensable during normal epidermal homeostasis in the adulthood, is again required for barrier repair after immune-mediated epidermal damage, regulates distinct gene batteries in embryonic epidermal differentiation and adult epidermal barrier reformation after injury. Plays unique and cooperative roles with GRHL2 in establishing distinct zones of primary neurulation. Essential for spinal closure, functions cooperatively with GRHL2 in closure 2 (forebrain/midbrain boundary) and posterior neuropore closure (By similarity). Also required for proper development of the oral periderm (PubMed:24360809). No genetic interaction with GRHL3, no functional cooperativity due to diverse target gene selectivity (PubMed:21081122).
Immunogen
Recombinant Human Grainyhead-like protein 3 homolog protein (31-182AA)

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 50 UG
Lieferbar: In stock
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