PRDM14 Antibody

Ice packs

For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals.

The antiserum was purified by peptide affinity chromatography.

Transcription factor that has both positive and negative roles on transcription. Required for the maintenance of emryonic stem cell identity and the reacquisition of pluripotency in somatic cells. May play an essential role in germ cell development at 2 levels: the reacquisition of potential pluripotency, including SOX2 up-regulation, and successful epigenetic reprogramming, characterized by EHMT1 repression. Its association with CBFA2T2 is required for the functions in pluripotency and germ cell formation (By similarity). Directly up-regulates the expression of pluripotency gene POU5F1 through its proximal enhancer. Binds to the DNA consensus sequence 5'-GGTC[TC]CTAA-3'.

WB 1:500-1:2000, IHC 1:50-1:200, IF 1:50-1:200, IP 1:20-1:100 CHIP 1:20-1:100

PRDM14 Antibody detects endogenous levels of total PRDM14