Antibodies

EIF2AK1 Polyclonal Antibody

Hersteller Biomatik
Kategorie
Typ Antibody Polyclonal
Specific against Human, Rat
Applikationen WB, IF, IHC, ELISA
Menge 50ug
Host Rabbit
ArtNr BM-CAC07983-50ug
Eclass 6.1 32160702
Eclass 9.0 32160702
Lieferbar
Immunogen
Recombinant Human Eukaryotic translation initiation factor 2-alpha kinase 1 protein (1-86AA)
Conjugate
Unconjugated
Alternative Names
Eukaryotic translation initiation factor 2-alpha kinase 1, Heme-controlled repressor, HCR, Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase, Heme-regulated inhibitor, Hemin-sensitive initiation factor 2-alpha kinase, EIF2AK1, HRI, KIAA1369, PRO1362
UniProt ID
Q9BQI3
Purification
Protein G purified, >95%
Storage Instructions
Aliquot and store at -20C. Minimize freezing and thawing.
Expiry Date
1 year
Shipping Condition
Blue ice
Comment
Inhibits protein synthesis at the translation initiation level, in response to various stress conditions, including oxidative stress, heme deficiency, osmotic shock and heat shock. Exerts its function through the phosphorylation of EIF2S1 at 'Ser-48' and 'Ser-51', thus preventing its recycling. Binds hemin forming a 1:1 complex through a cysteine thiolate and histidine nitrogenous coordination. This binding occurs with moderate affinity, allowing it to sense the heme concentration within the cell. Thanks to this unique heme-sensing capacity, plays a crucial role to shut off protein synthesis during acute heme-deficient conditions. In red blood cells (RBCs), controls hemoglobin synthesis ensuring a coordinated regulation of the synthesis of its heme and globin moieties. Thus plays an essential protective role for RBC survival in anemias of iron deficiency. Similarly, in hepatocytes, involved in heme-mediated translational control of CYP2B and CYP3A and possibly other hepatic P450 cytochromes. May also contain ER stress during acute heme-deficient conditions (By similarity).
Restriction
For research use only. Not for diagnostic procedures.
Menge: 50ug
Lieferbar: In stock
Listenpreis: 240,64 €
Preis: 240,64 €
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