Recombinant Human ATP-sensitive inward rectifier potassium channel 10 (KCNJ10)

Ice packs

58.5 kDa

For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals.

Not Tested

Membrane, Multi-pass membrane protein, Basolateral cell membrane

May be responsible for potassium buffering action of glial cells in the brain. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity). In the kidney, together with KCNJ16, mediates basolateral K(+) recycling in distal tubules; this process is critical for Na(+) reabsorption at the tubules.

Expressed in kidney (at protein level).

KCNJ10