Recombinant Human Interleukin-33 protein (IL33) (Active)

IL-33, IL-1F11, Nuclear factor from high endothelial venules, NF-HEV,

E.coli

SITGISPIT EYLASLSTYN DQSITFALED ESY EIYVEDL KKDEKKDKVLLSYYESQHPS NE SGD GVDGK MLMVTLSPTK DFWLHANNKE HSVELHK CEKPLPDQAFFVL HNMHSNCVSF ECKTDPGVFI GVKDNHLALI KVDSSENLCT ENILFKLSET

Tag-Free

>97% as determined by SDS-PAGE and HPLC.

Less than 1.0 EU/ug as determined by LAL method.

Ice packs

1 year

Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells (PubMed:16286016). Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an "alarmin", that amplifies immune responses during tissue injury (PubMed:17853410, PubMed:18836528). {ECO:0000269|PubMed:16286016, ECO:0000269|PubMed:17853410, ECO:0000269|PubMed:18836528}.; In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets (PubMed:21734074). This form is rapidely lost upon angiogenic or proinflammatory activation (PubMed:18787100). {ECO:0000269|PubMed:18787100, ECO:0000269|PubMed:21734074}.

Nucleus, Chromosome, Cytoplasmic vesicle, secretory vesicle, Secreted

Expressed at high level in high endothelial venules found in tonsils, Peyer patches and mesenteric lymph nodes. Almost undetectable in placenta.