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Recombinant Human Fibroblast growth factor 1 protein (FGF1) (Active)

Recombinant Human Fibroblast growth factor 1 protein (FGF1) (Active)

ArtNr	BM-RPC26791-1mg
Hersteller	Biomatik
Menge	1mg
Kategorie	Oncology Neuroscience Neural Signaling Neural Adhesion Molecules By Cell Type Carcinoma Glioma Hematology Myeloma Peptides & Proteins Recombinant Proteins Cell Biology Cell Culture Cytokines Cell Status Senescence By Organ Bladder Cancer
Typ	Proteins Recombinant
Specific against	Human (Homo sapiens)
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	FGF-1, aFGF, Endothelial cell growth factor, ECGF, Heparin-binding growth factor 1
Similar products	aFGF, ECGF, FGF-1, Heparin-binding growth factor 1, Endothelial cell growth factor
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Gene Name	FGF1, FGFA
Alternative Names	FGF-1, aFGF, Endothelial cell growth factor, ECGF, Heparin-binding growth factor 1
Uniprot	P05230
Source	E.coli
Expression Region	1-155aa
AA Sequence	MAEGEITTFT ALTEKFNLPP GNYKKPKLLY CS NGGHFLRI LPDGTVDGTR DRSDQHIQLQ LSAE SVGEVY IKSTETGQYL AMDTDGLLYG SQTPNE ECLF LERLEENHYN TYISKKHAEK NWFVGLKK NG SCKRGPRTHY GQKAILFLPL PVSSD
Sequence Info	Full Length
Tag Info	Tag-Free
Theoretical MW	17.5 kDa
Purity	>97% as determined by SDS-PAGE and HPLC.
Storage Buffer	Lyophilized from a 0.2 um filtered PBS, pH 7.4, with 2 mM EDTA, 0.5 mM DTT, 5 % Trehalose
Endotoxin Level	Less than 1.0 EU/ug as determined by LAL method.
Biological Activity	The ED50 as determined by a cell proliferation assay using murine balb/c 3T3 cells is less than 0.5 ng/ml, corresponding to a specific activity of ? 2.0 x 106 IU/mg in the presence of 10 ug/ml of heparin.
Shipping Condition	Ice packs
Storage	Short term: -20CC; Long term: -80CC. Minimize freeze and thaw cycles.
Expiry Date	1 year
Restriction	For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals.
Relevance	Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. {ECO:0000269\|PubMed:16597617, ECO:0000269\|PubMed:20145243, ECO:0000269\|PubMed:8663044}.
Function	Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV
Subcellular location	Secreted, Cytoplasm, Cytoplasm, cell cortex, Cytoplasm, cytosol, Nucleus
Protein Families	Heparin-binding growth factors family
Tissue Specificity	Predominantly expressed in kidney and brain. Detected at much lower levels in heart and skeletal muscle.
Paythway	Hipposignalingpathway

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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Menge: 1mg

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Lieferung vsl. bis 09.10.2025