Recombinant Mouse Tumor necrosis factor ligand superfamily member 11 (Tnfsf11), partial (Active)

Tnfsf11

O35235

73-316aa

Partial

28.5 kDa

Lyophilized from a 0.2 um filtered 20 mM PB, 150 mM NaCl, pH 7.4

The ED50 as determined by its ability to bind Human TNFRSF11B in functional ELISA is less than 10 ug/ml.

Short term: -20CC; Long term: -80CC. Minimize freeze and thaw cycles.

For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals.

Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy (By similarity). Induces osteoclastogenesis by activating multiple signaling pathways in osteoclast precursor cells, chief among which is induction of long lasting oscillations in the intracellular concentration of Ca (2+) resulting in the activation of NFATC1, which translocates to the nucleus and induces osteoclast-specific gene transcription to allow differentiation of osteoclasts

Isoform 1: Cell membrane, Single-pass type II membrane protein, SUBCELLULAR LOCATION: Isoform 2: Cell membrane, Single-pass type II membrane protein, SUBCELLULAR LOCATION: Isoform 3: Cytoplasm, SUBCELLULAR LOCATION: Tumor necrosis factor ligand superfamily member 11, soluble form: Secreted

Highly expressed in thymus and lymph nodes, but not in non-lymphoid tissues and is abundantly expressed in T-cells but not in B-cells. A high level expression is also seen in the trabecular bone and lung.