Mouse monoclonal antibody to human Neuropilin-1 [1B3]: IgG

The antibody is made against the membrane-bound isoform 1 of Neuropilin-1. It is a receptor involved in the development of the cardiovascular systerm, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It binds both vascular endothelial growth factor (VEGF) and semaphorin family members. Isoform 1 is expressed by blood vessels of different tissues. In the developing embryo it is predominantly found in the nervous system. In adult tissues, it is highly expressed in heart and placenta, moderately expressed in lung, liver and skeletal muscle, kidney and pancreas, and low in adult brain.