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Mouse monoclonal antibody to human ATG12 [2H8]: IgG

Mouse monoclonal antibody to human ATG12 [2H8]: IgG

ArtNr	M-879-100
Hersteller	Biosensis
Menge	100ug
Kategorie	Antibodies Cell Biology Cell Status Western Blot ELISA Autophagy Primary Antibodies
Typ	Antibody Monoclonal
Applikationen	WB, ELISA
Clon	2H8
Specific against	Human (Homo sapiens)
Host	Mouse
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Similar products	ATG12, APG12, APG12L, Autophagy-related protein 12, APG12-like
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Sub category	Autophagy
products_extra_fields_value	Autophagy is a process of bulk protein degradation in which cytoplasmic components, including organelles, are enclosed in double-membrane structures called autophagosomes and delivered to lysosomes or vacuoles for degradation. ATG12 is the human homolog of a yeast protein involved in autophagy.A ATG12 is conjugated to ATG5. The ATG12-ATG5 conjugate has an apparent molecular mass of 65 kDa. The C-terminal glycine of ATG12 is conjugated to a central lysine (lys130) of ATG5. Studies showed that over expression of ATG3 facilitated formation of the ATG12-ATG5 conjugate, suggesting that ATG3 cross-talks with the ATG12 conjugation system. ATG12 is ubiquitously expressed.
products_quantity	200
storage	After reconstitution keep aliquots at -20AC for higher stability or at 4AC with an appropriate antibacterial agent. Glycerol (1:1) may be added for additional stability. Avoid repetitive freeze/thaw cycles.
purityisotype	Protein G purified immunoglobulin
formulation	Lyophilised from PBS pH 7.2
immunogen	Full recombinant human ATG12, isoform 2, (1-74) with a GST tag.
crossreactivity	Human. Other species have not been tested.
conality	Mouse
specificity	Specificity has been confirmed by WB and direct ELISA against the antigen.
reconstitution	Reconstitute in 100 Aul of sterile water. Centrifuge to remove any insoluble material.
specificreferences	1. Garrido-Maraver J. et al (2012) Screening of effective pharmacological treatments for MELAS syndrome using yeasts, fibroblasts and cybrids models of the disease Br J Pharmacol. 2012 Jul 2. 2. De la Mata M. et al (2012) Recovery of MERRF fibroblasts and cybrids pathophysiology by Coenzyme Q₁, ₀, Neurotherapeutics. 2012 Apr, 9(2):446-63. 3. Bullon P et al (2012) Autophagy in periodontitis patients and gingival fibroblasts: unraveling the link between chronic diseases and inflammation. BMC Med. 2012 Oct 17, 10:122. 4. Rodriguez-Hernandez A et al (2009) Coenzyme Q deficiency triggers mitochondria degradation by mitophagy. Autophagy. 2009 Jan, 5(1):19-32.

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