Rabbit polyclonal to mouse Interleukin 1beta (IL-1beta) Affinity purified

Interleukin-1 beta (IL-1β, ) also know as catabolin, is a cytokine protein that in humans is encoded by the IL1B gene, which localizes to the long arm of chromosome 2. Interleukin 1 was discovered by Gery in 1972. He named it lymphocyte-activating factor (LAF) because it was a lymphocyte mitogen. It was not until 1985 that interleukin 1 was discovered to consist of two distinct proteins, now called interleukin-1 alpha and interleukin-1 beta. IL-1β, is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. Reference: http://en.wikipedia.org/wiki/IL1B
Biosensis rabbit polyclonal to mouse IL-1β, has been tested against mouse tissues and reacts well in western blots. Other applications and other species have not yet been tested.

At -20˚, C for one year. After reconstitution, at 4˚, C for one month. It can also be aliquotted and stored frozen at -20˚, C for a longer time. Avoid repeated freezing and thawing.

affinity purified

Other species not yet tested

Mouse, other species not yet tested