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Mouse monoclonal antibody to Microtubule-associated protein tau

Mouse monoclonal antibody to Microtubule-associated protein tau

ArtNr	M-1703-100
Hersteller	Biosensis
Menge	100uL
Kategorie	Neuroscience Molecular Targets for Neuroscience Targets for Rodent Neurosciences Aging & Neurological Disorders Protein Aggregation, Clearance & Misfolding Antibodies Cell Biology Cell Status Apoptosis Western Blot Immunocytochemistry Primary Antibodies
Typ	Antibody Monoclonal
Applikationen	WB, ICC
Specific against	other
Host	Mouse
Isotype	IgG1
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Similar products	MAPT, TAU, MTBT1, Neurofibrillary tangle protein, Paired helical filament-tau, PHF-tau
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Sub category	Alzheimer's / Parkinson's
products_extra_fields_value	FUNCTION: Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.A SUBCELLULAR LOCATION: Cytoplasm, cytosol. Cell membrane. Mostly found in the axons of neurons, in the cytosol and in association with plasma membrane components. ALTERNATIVE PRODUCTS: 8 named isoforms produced by alternative splicing. Additional isoforms seem to exist. Isoforms differ from each other by the presence or absence of up to 5 of the 15 exons. One of these optional exons contains the additional tau/MAP repeat. TISSUE SPECIFICITY: Expressed in neurons. Isoform PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system. DEVELOPMENTAL STAGE: Four-repeat (type II) tau is expressed in an adult-specific manner and is not found in fetal brain, whereas three-repeat (type I) tau is found in both adult and fetal brain. DOMAIN: The tau/MAP repeat binds to tubulin. In Alzheimer disease, the neuronal cytoskeleton in the brain is progressively disrupted and replaced by tangles of paired helical filamentsA and straight filaments, mainly composed of hyperphosphorylated forms of Microtubule-associated protein Tau. Defects in Microtubule-associated protein Tau are a cause of frontotemporal dementia and parkinsonism linked to chromosome 17, as well as a number of other neurodegenerative diseases.
products_quantity	200
storage	Maintain lyophilized material at 2-8AC. After reconstitution of lyophilized antibody, aliquot and store at -20AC for a higher stability. Avoid freeze-thaw cycles.
formulation	Lyophilised purified culture supernatant with 5% trehalose and 0.5% sodium azide.
immunogen	Recombinant full length version of the shortest human tau isoform purified from E. coli.
conality	Mouse
specificity	The antibody reacts with multiple closely spaced bands covering the region of the blot from 48kDa to 67kDa. It has also been used successfully for immunocytochemistry.
reconstitution	Reconstitute in sterile distilled water. Centrifuge to remove any insoluble material.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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Menge: 100uL

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Lieferung vsl. bis 13.11.2025

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