Human Nerve Growth Factor Receptor-Fc Chimera (209 amino acids) expressed in mammalian cells

Nerve growth factor (NGF) receptor, also known as p75NTR, A is a low affinity NGF receptor. It binds with equal affinity neurotrophins such as beta NGF, BDNF, NT-3 and NT-4. NGF receptors mediate signaling of neurotrophins for neuronal survival, apoptosis, neurite outgrowth and synaptic plasticity. These receptors are also thought to play a role in neurogenerative diseases such as Alzheimers disease. The NGF receptor is a type I transmembrane glycoprotein (399 aa) consisting of a signal peptide (28 aa), an extracellular domain (222 aa) which contains four cysteine rich domains responsible for ligand binding, a transmembrane domain (22 aa) and a cytoplasmic domain (155 aa).

Lyophilized products should be stored at 2-8AC. Following reconstitution, short-term storage at 4AC is recommended and longer-term storage of aliquots at -18 to -20AC. Repeated freeze thawing is not recommended.

The NGF Receptor-Fc chimera consists of 25-45% carbohydrate by weight.

It is recommended that 0.5 ml of sterile phosphate-buffered saline (PBS) be added to the vial. When reconstituted in 0.5ml of PBS, the solution will contain 1% human serum albumin (HSA) and 10% trehalose.