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Human Epidermal Growth Factor Receptor-Fc Chimera expressed in mammalian cells

Human Epidermal Growth Factor Receptor-Fc Chimera expressed in mammalian cells

ArtNr	PE-1240-25
Hersteller	Biosensis
Menge	25ug
Kategorie	Oncology Neuroscience Neural Signaling Protein Aggregation, Clearance & Misfolding By Cell Type Blastoma Carcinoma Glioma Hematology Leukemia Lymphoma Myeloma Melanoma Sarcoma Peptides & Proteins Recombinant Proteins Cell Biology Cell Culture Cytokines Adenocarcinoma Astrocytoma By Organ Bladder Cancer Heart & Blood Cancer
Typ	Proteins
Specific against	other
Host	Human
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Similar products	EGFR, ERBB1, Receptor tyrosine-protein kinase erbB-1, Pro-epidermal growth factor, Urogastrone, EGF R, c-erbB-1
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Sub category	Receptor Body Chimeras
products_extra_fields_value	Epidermal Growth Factor (EGF) Receptor binds to EGF and other members of the EGF family such as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. At least 4 isoforms are produced by alternative splicing (reference SWISSPROT). The EGF receptor is a single-pass type I membrane protein containing an extracellular receptor domain, a transmembrane region and an intracellular domain with tyrosine kinase function.
products_quantity	200
storage	Lyophilized products should be stored at 2 to 8AC. Following reconstitution short-term storage at 4AC is recommended, with longer-term storage in aliquots at -18 to -20AC. Repeated freeze thawing is not recommended.
purityisotype	>95%, as determined by SDS-PAGE and visualized by Coomassie Brilliant Blue
formulation	The EGF receptor-Fc chimera consists of 5-30% carbohydrate by weight. When reconstituted in 0.5 ml sterile phosphate-buffered saline, the solution will contain 1% human serum albumin (HSA) and 10% trehalose.
conality	Human - A DNA sequence encoding the signal peptide and extracellular domain of human Epidermal Growth Factor Receptor (amino acids 1-525) was fused to the Fc region of human IgG1 (amino acids 90-330). The chimeric protein was expressed in modified human 293 cells.
reconstitution	It is recommended that 0.5 ml of sterile phosphate-buffered saline be added to the vial.

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