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MMP 2 (Progelatinase A) Europäischer Partner

ArtNr BTZ-30100602
Hersteller BioTeZ
Menge 10 ug/50ul
Kategorie
Typ Proteins Recombinant
Format Liquid
Specific against Human (Homo sapiens)
Protein Familie Matrix Metalloproteinases, matrixins
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Lieferbar
Purity
> 95 %
Product Subcategory
EC 3.4.24.24
Pathway and Disease
Diseases associated with MMP2 include Multicentric Osteolysis, Nodulosis, And Arthropathy and Multicentric Osteolysis Of Torg. Among its related pathways are Pathways in cancer and Integrin Pathway
Description
MMP2 is a ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly- -Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues in association with MMP14.
Applications Info
Degradation of extracellular Matrix, Screening and evaluation of MMP inhibitors, Antigen standard
Alternate Names
Matrix Metalloproteinase 2, Progelatinase A, a 72kDa Type IV Collagenase
Sequence
MEALMARGALTGPLRALCLLGCLLSHAAAAPSPII KFPGDVAPKTDKELAVQYLNTFYGCPKESCNLFVL KDTLKMQKFFGLPQTGDLDQNTIETMRKPRCGNPD VANYNFFPRKPKWDKNQITYRIIGYTPDLDPETVD DAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRW EHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDE LWTLGEGQVVRVKYGNADGEYCKFPFLFNGKEYNS CTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFT MGGNAEGQPCKFPFRFQGTYDSCTTEGRTDGYRWC GTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFP FTFLGNKYESCTSAGRSDGKMWCATTANYDDDRKW GFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMA PIYTYTKNFRLSQDDIKGIQELYGASPDIDLGTGP TPTLGPVTPEICKQDIVFDGIAQIRGEIFFFKDRF IWRTVTPRDKPMGPLLVATFWPELPEKIDAVYEAP QEEKAVFFAGNEYWIYSASTLERGYPKPLTSLGLP PDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKK MDPGFPKLIADAWNAIPDNLDAVVDLQGGGHSYFF KGAYYLKLENQSLKSVKFGSIKSDWLGC
Accession No
P08253
Composition
50 mM Tris-HCl, pH 7.0, 200 mM NaCl, 5 mM CaCl2, 0.05 % Brij-35
Storage
Store at -70C
Target Modification
No
Expression System
Insect Cell
Product Subtype
full length
Active?
Yes, after APMA activation
Tag
untagged
Gene ID
4313
Molecular Weight
72 kDa
Shipping Temp Min
dry ice
Product description long
MMP2 is expressed in Sf9-insect cells using the baculovirus expression vector system and purified from cell culture supernatant.
Purification
Mentioned in the data sheet
Restrictions
For Research Use only.
NCBI Official Symbol
MMP2

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 10 ug/50ul
Lieferbar: In stock
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