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MMP 13 (Collagenase 3) catalytic domain

MMP 13 (Collagenase 3) catalytic domain

ArtNr	BTZ-30100812
Hersteller	BioTeZ
Menge	10 ug/50ul
Kategorie	Neuroscience Neuroinflammation Molecular Targets for Neuroscience Peptides & Proteins Recombinant Proteins Cell Biology Cell Stainings ECM
Typ	Proteins Recombinant
Format	Liquid
Specific against	Human (Homo sapiens)
Protein Familie	Matrix Metalloproteinases, matrixins
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Lieferbar
Purity	>95%
Product Subcategory	EC 3.4.24.35
Pathway and Disease	Diseases associated with MMP13 include Spondyloepimetaphyseal Dysplasia, Missouri Type and Metaphyseal Dysplasia, Spahr Type. Among its related pathways are Integrin Pathway and Development_Glucocorticoid receptor signaling.
Description	MMP13 plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CTGF. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CTGF. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion
Applications Info	Degradation of extracellular Matrix, Screening and evaluation of MMP inhibitors, Antigen standard
Alternate Names	Matrix Metalloproteinase 13 (Collagenase 3)
Sequence	Y N V F P R T L K W S K M N L T Y R I V N Y T P D M T H S E V E K A F K K A F K V W S D V T P L N F T R L H D G I A D I M I S F G I K E H G D F Y P F D G P S G L L A H A F P P G P N Y G G D A H F D D D E T W T S S S K G Y N L F L V A A H E F G H S L G L D H S K D P G A L M F P I Y T Y T G K S H F M L P D D D V Q G I Q S L Y G P G D E D P N
Accession No	P45452
Composition	50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 5 mM CaCl2
Storage	Store at -70C
Target Modification	No
Expression System	E.coli
Product Subtype	protein fragment
Active?	Yes
Tag	untagged
Gene ID	4322
Molecular Weight	19.5 kDa
Shipping Temp Min	dry ice
Product description long	Recombinant human procollagenase-3 catalytic domain is expressed in E. coli.
Purification	Mentioned in the data sheet
Restrictions	For Research Use only.
NCBI Official Symbol	MMP13 (partial)

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Menge: 10 ug/50ul

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