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MMP 24 (MT5-MMP) catalytic domain, His-tagged

MMP 24 (MT5-MMP) catalytic domain, His-tagged

ArtNr	BTZ-30100902
Hersteller	BioTeZ
Menge	10 ug/50ul
Kategorie	Neuroscience Neuroinflammation Aging & Neurological Disorders Peptides & Proteins Recombinant Proteins
Typ	Proteins Recombinant
Format	Liquid
Specific against	Human (Homo sapiens)
Konjugat/Tag	His
Protein Familie	Matrix Metalloproteinases, matrixins
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Lieferbar
Purity	> 90 %
Product Subcategory	EC 3.4.24.80
Pathway and Disease	Among MMP24 related pathways are Matrix Metalloproteinases and Degradation of the extracellular matrix.
Description	MMP24 is a metalloprotease that mediates cleavage of N-cadherin (CDH2) and acts as a regulator of neuro-immune interactions and neural stem cell quiescence. Involved in cell-cell interactions between nociceptive neurites and mast cells, possibly by mediating cleavage of CDH2, thereby acting as a mediator of peripheral thermal nociception and inflammatory hyperalgesia. Key regulator of neural stem cells quiescence by mediating cleavage of CDH2, affecting CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate their quiescence. May play a role in axonal growth. Able to activate progelatinase A. May also be a proteoglycanase involved in degradation of proteoglycans, such as dermatan sulfate and chondroitin sulfate proteoglycans. Cleaves partially fibronectin, but not collagen type I, nor laminin (By similarity).
Applications Info	Activation of progelatinase A, Degradation of extracellular Matrix, Screening and evaluation of MMP inhibitors, Antigen standard
Alternate Names	Membrane-Type 5 Matrix Metalloproteinase
Sequence	Y A L T G Q K W R Q K H I T Y S I H N Y T P K V G E L D T R K A I R Q A F D V W Q K V T P L T F E E V P Y H E I K S D R K E A D I M I F F A S G F H G D S S P F D G E G G F L A H A Y F P G P G I G G D T H F D S D E P W T L G N A N H D G N D L F L V A V H E L G H A L G L E H S S D P S A I M A P F Y Q Y M E T H N F K L P Q D D L Q G I Q K I Y G P P A E P L E P T R P L P T L P V R R I H S P S V T H H H H H H
Accession No	Q9Y5R2
Composition	50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 5 mM CaCl2.
Storage	Store at -70C
Target Modification	No
Expression System	E.coli
Product Subtype	protein fragment
Active?	Yes
Tag	His-tagged
Gene ID	10893
Molecular Weight	22 kDa
Shipping Temp Min	dry ice
Product description long	The catalytic domain of human MT5-MMP is produced by activation of a recombinant soluble proform of MT5-MMP purified from E. coli periplasm.
Purification	Mentioned in the data sheet
Restrictions	For Research Use only.
NCBI Official Symbol	MMP24 (partial)

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Menge: 10 ug/50ul

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