Hersteller |
Bioworld Technology, Inc
|
Kategorie |
|
Typ |
Antibody Monoclonal |
Specific against |
Human |
Applikationen |
WB, IHC |
Menge |
100ul |
Host |
Mouse |
ArtNr |
MB0080-100 |
Targets |
PPARA ;;PPARG |
eClass 6.1 |
32160702 |
eClass 9.0 |
42030590 |
Lieferbar |
|
Swiss-Prot |
P37231 |
Application all |
WB: 1:1000 |
Background |
PPAR gamma is implicated in numerous diseases including obesity, diabetes, atherosclerosis and cancer. PPAR gamma activators include prostanoids, fatty acids, thiazolidinediones and N-(2-benzoylphenyl) tyrosine analogues. A key component in adipocyte differentiation and fat-specific gene expression, PPAR gamma may modulate macrophage functions such as proinflammatory activities, and stimulate oxidized low-density lipoprotein (x-LDL) uptake. A Pro12Ala polymorphism of the PPAR gamma2 gene has been reported to reduce transactivation activity in vitro. This substitution may affect the immune response to ox-LDL and be associated with type 2 diabetes. In addition, the Pro12Ala variant of the PPAR gamma2 gene maybe correlated with abdominal obesity in type 2 diabetes. |
Product |
Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50%, glycerol |
Purification and Purity |
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE). |
Storage and Stability |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
Specificity |
This antibody detects endogenous levels of PPAR gamma (C-terminus) and does not cross-react with related proteins |
WB |
Western blot detection of PPAR gamma antibody in 3T3-L1&Mouse Lung cell lysates using PPAR gamma antibody (1:1000 diluted) . |
BiowMW |
Predicted band size:54KDa Observed band size:54KD |
Note |
For research use only, not for use in diagnostic procedure. |
Alternative Name |
Peroxisome proliferator-activated receptor gamma, Short name=PPAR-gamma, Nuclear receptor subfamily 1 group C member 3, PPARG, NR1C3, PPAR gamma, PPARgamma |
Immunogen |
Synthetic peptide, corresponding to amino acids C-terminus of Human PPAR-gamma. |
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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.