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PPAR-gamma (E157) polyclonal antibody

PPAR-gamma (E157) polyclonal antibody

Hersteller	Bioworld Technology, Inc
Kategorie	Metabolism Diabetes Glucose Homeostasis Cholesterol & Lipid Metabolism Antibodies Western Blot Cardiovascular Research Atherosclerosis Primary Antibodies Other Lipid\Cholesterol Metabolism Modulators
Typ	Antibody Polyclonal
Specific against	Human, Mouse, Rat
Applikationen	WB
Menge	50ul
Host	Rabbit
ArtNr	AP0688-50
Targets	PPARA ;;PPARG
eClass 6.1	32160702
eClass 9.0	32160702
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Swiss-Prot	P37231
Application all	WB: 1:500ca.1:1000
Background	PPAR gamma is implicated in numerous diseases including obesity, diabetes, atherosclerosis and cancer. PPAR gamma activators include prostanoids, fatty acids, thiazolidinediones and N-(2-benzoylphenyl) tyrosine analogues. A key component in adipocyte differentiation and fat-specific gene expression, PPAR gamma may modulate macrophage functions such as proinflammatory activities, and stimulate oxidized low-density lipoprotein (x-LDL) uptake. A Pro12Ala polymorphism of the PPAR gamma2 gene has been reported to reduce transactivation activity in vitro. This substitution may affect the immune response to ox-LDL and be associated with type 2 diabetes. In addition, the Pro12Ala variant of the PPAR gamma2 gene maybe correlated with abdominal obesity in type 2 diabetes.
Product	1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
Purification and Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage and Stability	Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Specificity	PPAR-gamma (E157) pAb detects endogenous levels of PPAR gamma protein.
WB	Western blot (WB) analysis of PPAR-gamma (E157) pAb at 1:500 dilution Lane1:HEK293T whole cell lysate Lane2:Raw264.7 whole cell lysate Lane3:H9C2 whole cell lysate
BiowMW	ca. 54 kDa
Note	For research use only, not for use in diagnostic procedure.
Alternative Name	Peroxisome proliferator-activated receptor gamma, Short name=PPAR-gamma, Nuclear receptor subfamily 1 group C member 3, PPARG, NR1C3, PPAR gamma, PPARgamma
Immunogen	Synthetic peptide, corresponding to amino acids 150-200 of Human PPAR-gamma.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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