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APP/beta-Amyloid (E737) polyclonal antibody

APP/beta-Amyloid (E737) polyclonal antibody

Hersteller	Bioworld Technology, Inc
Kategorie	Neuroscience Molecular Targets for Neuroscience Aging & Neurological Disorders Protein Aggregation, Clearance & Misfolding Antibodies Immunohistochemistry Western Blot Immunofluorescence Primary Antibodies
Typ	Antibody Polyclonal
Specific against	Human, Mouse, Rat
Applikationen	WB, IF, IHC
Menge	50ul
Host	Rabbit
ArtNr	BS1011-50
Targets	APP
eClass 6.1	32160702
eClass 9.0	32160702
Lieferbar
Swiss-Prot	P05067
Application all	WB: 1:500ca.1:1000 IHC: 1:50ca.1:200 IF: 1:50ca.1:200
Background	Proteolytic cleavage of the Amyloid protein precursor (APP) gives rise to the beta-Amyloid and Amyloid A4 proteins, which are present in human platelets. Amyloid deposition is associated with type II diabetes, Down syndrome and a variety of neurological disorders, including Alzheimer's disease. The Amyloid precursor protein (APP) undergoes alternative splicing, resulting in several isoforms. Proteolytic cleavage of APP leads to the formation of the Amyloid beta/A4 Amyloid protein. This protein is involved in the formation of neurofibrillary tangles and plaques that characterize the senile plaques of Alzheimer's patients. APLP1 (Amyloid precursor-like protein 1) and APLP2 are structurally similar to APP.
Product	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Purification and Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage and Stability	Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Specificity	APP/beta-Amyloid (E737) pAb detects endogenous levels of several isoforms of both mature and immature beta-amyloid A4 precursor protein, including APP639, APP677, APP695, APP696, APP714, APP733, APP751 and APP752.
WB	Western blot (WB) analysis of APP/beta-Amyloid (E737) pAb at 1:500 dilution Lane1:MCF-7 cell lysate Lane2:sp2/0 cell lysate Lane3:H9C2 cell lysate
IHC	Immunohistochemistry (IHC) analyzes of APP/beta-Amyloid (E737) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.
BiowMW	ca. 70 to140 kDa
Note	For research use only, not for use in diagnostic procedure.
Alternative Name	Amyloid beta A4 protein, ABPP, APPI, Short name=APP, Alzheimer disease amyloid protein, Cerebral vascular amyloid peptide, Short name=CVAP, PreA4, Protease nexin-II, Short name=PN-II, N-APP, Soluble APP-alpha, Short name=S-APP-alpha, Soluble APP-beta, Short name=S-APP-beta, Beta-amyloid protein 42, Beta-APP42, Beta-amyloid protein 40, Beta-APP40, P3(42), P3(40), Gamma-secretase C-terminal fragment 59, Amyloid intracellular domain 59, Short name=AICD-59, Short name=AID(59), Gamma-CTF(59), Gamma-secretase C-terminal fragment 57, Amyloid intracellular domain 57, Short name=AICD-57, Short name=AID(57), Gamma-CTF(57), Gamma-secretase C-terminal fragment 50, Amyloid intracellular domain 50, AICD-50, AID(50), Gamma-CTF(50), APP, A4, AD, Amyloid-beta, Amyloid beta, Amyloidbeta, beta Amyloid, betaAmyloid, Abeta
Immunogen	Synthetic peptide, corresponding to amino acids 701-750 of Human APP/beta-Amyloid.

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