PIG11 (P93) polyclonal antibody

O14683

PIG11 (p53-induced gene 11 protein), also known as TP53I11, is a 177 amino acid tumor suppressor belonging to the p53-induced protein gene (PIG) family. The PIG gene family encodes redox-controlling proteins that are involved in p53 tumor suppressor activity. It is suggested that PIG11 is involved in arsenic trioxide As(2)O(3)-induced apoptosis in certain cell lines and may play a significant role in tumor suppression through promotion of cell apoptosis. The gene encoding PIG11 maps to human chromosome 11, which houses over 1, 400 genes and comprises nearly 4% of the human genome. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are associated with defects in genes that maps to chromosome 11.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

PIG11 (P93) pAb detects endogenous levels of PIG11 protein.

Immunohistochemistry (IHC) analyzes of PIG11 (P93) pAb in paraffin-embedded human colorectal carcinoma tissue at 1:50.

For research use only, not for use in diagnostic procedure.

Synthetic peptide, corresponding to amino acids 71-120 of Human PIG11.