Hersteller |
Bioworld Technology, Inc
|
Kategorie |
|
Typ |
Antibody Polyclonal |
Specific against |
Human, Mouse, Rat |
Applikationen |
WB, IHC |
Menge |
100ul |
Host |
Rabbit |
ArtNr |
BS4121-100 |
Targets |
MEF2A;;MYEF2 |
eClass 6.1 |
32160702 |
eClass 9.0 |
32160702 |
Lieferbar |
|
Swiss-Prot |
Q02078 |
Application all |
WB: 1:500ca.1:1000 IHC: 1:50ca.1:200 |
Background |
The myocyte enhancer factor-2 (MEF-2) family of transcription factors associated with co-repessors or co-activators to regulate development and function of T cells, neuronal cells and muscle cells. Four family members arise from alternatively spliced transcripts, termed MEF-2A, -2B, -2C and -2D. These members bind as homo- and heterodimers to the MEF-2 site in the promoter region of affected genes. Differential regulation in the expression of the four transcripts implies functional distinction for each during embryogenesis and development. The process of differentiation from mesodermal precursor cells to myoblasts has led to the discovery of a variety of tissue-specific factors that regulate muscle gene expression. |
Product |
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. |
Purification and Purity |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE). |
Storage and Stability |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
Specificity |
p-MEF-2 (T319) pAb detects endogenous levels of MEF-2 protein only when phosphorylated at Thr319 |
IHC |
Immunohistochemistry (IHC) analyzes of p-MEF-2 (T319) pAb in paraffin-embedded human breast carcinoma tissue at 1:100. |
BiowMW |
ca. 55 kDa |
Note |
For research use only, not for use in diagnostic procedure. |
Alternative Name |
Myocyte-specific enhancer factor 2A, Serum response factor-like protein 1, MEF2A, MEF2 |
Immunogen |
Synthetic phosphopeptide derived from human MEF-2 around the phosphorylation site of Threonine 319. |
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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.