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PPARgamma (phospho-S112) polyclonal antibody

PPARgamma (phospho-S112) polyclonal antibody

Hersteller	Bioworld Technology, Inc
Kategorie	Metabolism Diabetes Glucose Homeostasis Cholesterol & Lipid Metabolism Antibodies Immunohistochemistry Western Blot Cardiovascular Research Atherosclerosis Primary Antibodies Other Lipid\Cholesterol Metabolism Modulators
Typ	Antibody Polyclonal
Specific against	Human, Mouse, Rat
Applikationen	WB, IHC
Menge	50ul
Host	Rabbit
ArtNr	BS4444-50
Targets	PPARA ;;PPARG
eClass 6.1	32160702
eClass 9.0	32160702
Lieferbar
Swiss-Prot	P37231
Application all	WB: 1:500ca.1:1000 IHC: 1:50ca.1:200
Background	PPAR gamma is implicated in numerous diseases including obesity, diabetes, atherosclerosis and cancer. PPAR gamma activators include prostanoids, fatty acids, thiazolidinediones and N-(2-benzoylphenyl) tyrosine analogues. A key component in adipocyte differentiation and fat-specific gene expression, PPAR gamma may modulate macrophage functions such as proinflammatory activities, and stimulate oxidized low-density lipoprotein (x-LDL) uptake. A Pro12Ala polymorphism of the PPAR gamma2 gene has been reported to reduce transactivation activity in vitro. This substitution may affect the immune response to ox-LDL and be associated with type 2 diabetes. In addition, the Pro12Ala variant of the PPAR gamma2 gene maybe correlated with abdominal obesity in type 2 diabetes.
Product	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Purification and Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage and Stability	Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Specificity	p-PPARgamma (S112) pAb detects endogenous levels of PPARgamma protein only when phosphorylated at Ser112.
WB	Western blot (WB) analysis of p-PPAR-gamma (S112) pAb at 1:500 dilution Lane1:Hela cell lysate treated with colchicine Lane2:Raw264.7 cell lysate treated with colchicine Lane3:PC12 cell lysate treated with colchicine
IHC	Immunohistochemistry (IHC) analyzes of p-PPARgamma (S112) pAb in paraffin-embedded human breast carcinoma tissue at 1:50.
BiowMW	ca. 54 kDa
Note	For research use only, not for use in diagnostic procedure.
Alternative Name	Peroxisome proliferator-activated receptor gamma, Short name=PPAR-gamma, Nuclear receptor subfamily 1 group C member 3, PPARG, NR1C3, PPAR gamma, PPARgamma
Immunogen	Synthetic phosphopeptide derived from human PPARgamma around the phosphorylation site of Serine 112.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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