Cytokeratin 5 polyclonal antibody

P13647

Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed as pairs in both keratinized and non-keratinized epithelial tissue. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. Cytokeratins have been found to be useful markers of tissue differentiation which is directly applicable to the characterization of malignant tumors. Cytokeratin 5 is expressed in normal basal cells. Mutations of the Cytokeratin 5 gene (KRT5) have been shown to result in the autosomal dominant disorder epidermolysis bullosa (EB).

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Cytokeratin 5 pAb detects endogenous levels of Cytokeratin 5 protein.

Immunofluorescence analysis of Hela cells, using Cytokeratin 5 polyclonal antibody

For research use only, not for use in diagnostic procedure.

Recombinant full length Human Cytokeratin 5.