LAMC2 polyclonal antibody

Q13753

Laminins are essential and abundant structural non-collagenous glycoproteins localizing to basement membranes. Basement membranes (cell-associated extracellular matrices (ECMs)) are polymers of laminins with stabilizing Type IV Collagen networks, nidogen and several proteoglycans. Basement membranes are found under epithelial layers, around the endothelium of blood vessels, and surrounding muscle, peripheral nerve and fat cells. Formation of basement membranes influences cell proliferation, phenotype, migration, gene expression and tissue architecture. Each laminin is a heterotrimer of ?, ? and ? chain subunits that undergoes cell-secretion and incorporation into the ECM. Laminins can self-assemble, bind to other matrix macromolecules, and have unique and shared cell interactions mediated by Integrins, dystroglycan and cognate laminin receptors. The human Laminin g-2 gene maps to chromosome 1q25.3 and specifically localizes to epithelial cells in skin, lung and kidney.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

LAMC2 polyclonal antibody detects endogenous levels of LAMC2 protein.

For research use only, not for use in diagnostic procedure.

Recombinant full length Human LAMC2.