Anti-Stat3 (T721) Antibody

Primary Antibodies

88068 MW

WB: 1:500-1:1000
IHC: 1:50-1:200
IF: 1:50-1:200

Signal transducer and activator of transcription 3

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

1 mg/ml

Signal transducer and transcription activator that
mediates cellular responses to interleukins, KITLG/SCF, LEP and
other growth factors (PubMed:10688651, PubMed:12359225,
PubMed:12873986, PubMed:15194700, PubMed:17344214,
PubMed:18242580, PubMed:23084476). Once activated, recruits
coactivators, such as NCOA1 or MED1, to the promoter region of the
target gene (PubMed:17344214). May mediate cellular responses to
activated FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:12873986). Binds
to the interleukin-6 (IL-6)-responsive elements identified in the
promoters of various acute-phase protein genes (PubMed:12359225).
Activated by IL31 through IL31RA (PubMed:15194700). Acts as a
regulator of inflammatory response by regulating differentiation
of naive CD4 (+) T-cells into T-helper Th17 or regulatory T-cells
(Treg): deacetylation and oxidation of lysine residues by LOXL3,
leads to disrupt STAT3 dimerization and inhibit its transcription
activity (PubMed:28065600). Involved in cell cycle regulation by
inducing the expression of key genes for the progression from G1
to S phase, such as CCND1 (PubMed:17344214). Mediates the effects
of LEP on melanocortin production, body energy homeostasis and
lactation (By similarity). May play an apoptotic role by
transctivating BIRC5 expression under LEP activation
(PubMed:18242580). Cytoplasmic STAT3 represses macroautophagy by
inhibiting EIF2AK2/PKR activity (PubMed:23084476). Plays a crucial
role in basal beta cell functions, such as regulation of insulin
secretion (By similarity).

Boster Bio Anti-Stat3 (T721) Antibody catalog # A00007T721. Tested in WB, IHC, IF applications. This antibody reacts with Human, Mouse, Rat.