Anti-CXCR4 (phospho-S339) Antibody

Primary Antibodies

39746 MW

WB: 1:500-1:1000

C-X-C chemokine receptor type 4

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

1 mg/ml

Receptor for the C-X-C chemokine CXCL12/SDF-1 that
transduces a signal by increasing intracellular calcium ion levels
and enhancing MAPK1/MAPK3 activation (PubMed:10452968,
PubMed:28978524, PubMed:18799424, PubMed:24912431). Involved in
the AKT signaling cascade (PubMed:24912431). Plays a role in
regulation of cell migration, e.g. during wound healing
(PubMed:28978524). Acts as a receptor for extracellular ubiquitin;
leading to enhanced intracellular calcium ions and reduced
cellular cAMP levels (PubMed:20228059). Binds bacterial
lipopolysaccharide (LPS) et mediates LPS-induced inflammatory
response, including TNF secretion by monocytes (PubMed:11276205).
Involved in hematopoiesis and in cardiac ventricular septum
formation. Also plays an essential role in vascularization of the
gastrointestinal tract, probably by regulating vascular branching
and/or remodeling processes in endothelial cells. Involved in
cerebellar development. In the CNS, could mediate hippocampal-
neuron survival (By similarity).

Boster Bio Anti-CXCR4 (phospho-S339) Antibody catalog # A00031S339. Tested in WB applications. This antibody reacts with Human.