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Anti-Phospho-Bax (S184) Antibody Europäischer Partner

ArtNr BOS-A00183S184
Hersteller Boster
Menge 100 ul
Kategorie
Format Liquid
Applikationen IF, IHC, ELISA
Specific against Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host Rabbit
Isotype IgG
Alias Apoptosis regulator BAX,Bcl-2-like protein 4,Bcl2-L-4,BAX,BCL2L4
Lieferbar
Manufacturer - Category
Primary Antibodies
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Molecular Weight
21184 MW
Clonality
Polyclonal
Application Details
IHC 1:100-1:300
ELISA 1:10000
IF 1:50-200
Gene Name
BAX
Gene Full Name
Apoptosis regulator BAX
Immunogen
The antiserum was produced against synthesized peptide derived from human Bax around the phosphorylation site of Ser184. AA range:143-192
Contents
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Protein Name
Apoptosis regulator BAX
Protein Function
Plays a role in the mitochondrial apoptotic process.
Under normal conditions, BAX is largely cytosolic via constant
retrotranslocation from mitochondria to the cytosol mediated by
BCL2L1/Bcl-xL, which avoids accumulation of toxic BAX levels at
the mitochondrial outer membrane (MOM) (PubMed:21458670). Under
stress conditions, undergoes a conformation change that causes
translocation to the mitochondrion membrane, leading to the
release of cytochrome c that then triggers apoptosis. Promotes
activation of CASP3, and thereby apoptosis.
Subcellular Localization
Isoform Alpha: Mitochondrion membrane;
Single-pass membrane protein. Cytoplasm
Description
Boster Bio Anti-Phospho-Bax (S184) Antibody catalog # A00183S184. Tested in IHC, IF, ELISA applications. This antibody reacts with Human, Mouse, Rat.
Tissue Specificity
Expressed in a wide variety of tissues.
Isoform Psi is found in glial tumors. Isoform Alpha is expressed
in spleen, breast, ovary, testis, colon and brain, and at low
levels in skin and lung. Isoform Sigma is expressed in spleen,
breast, ovary, testis, lung, colon, brain and at low levels in
skin. Isoform Alpha and isoform Sigma are expressed in pro-
myelocytic leukemia, histiocytic lymphoma, Burkitt's lymphoma, T-
cell lymphoma, lymphoblastic leukemia, breast adenocarcinoma,
ovary adenocarcinoma, prostate carcinoma, prostate adenocarcinoma,
lung carcinoma, epidermoid carcinoma, small cell lung carcinoma
and colon adenocarcinoma cell lines.
Short Description
Boster Bio Anti-Phospho-Bax (S184) Antibody catalog # A00183S184. Tested in ELISA, IHC applications. This antibody reacts with Human, Mouse, Rat.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 100 ul
Lieferbar: In stock
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