Anti-IL-15 Antibody

Primary Antibodies

18086 MW

IL-15 antibody can be used for detection of IL-15 by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in rat samples and Immunohistochemistry in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.

Interleukin 15

Interleukin 15 (IL-15) is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and IL-2 share many biological activities as both have been found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between IL-15 and IL-2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. In mouse, studies suggest that IL-15 may increase the expression of apoptosis inhibitor Bcl-xL, possibly through the transcription activation activity of STAT6, and thus prevent apoptosis.

IL-15 Antibody is supplied in PBS containing 0.02% sodium azide.

1 mg/mL

Interleukin 15

Isoform IL15-S48AA: Secreted.

Most abundant in placenta and skeletal muscle.
It is also detected in the heart, lung, liver and kidney. IL15-
S21AA is preferentially expressed in tissues such as testis and
thymus.

At least two isoforms of IL-15 are known to exist.