Anti-PI3K p85 Alpha /p55 Gamma (Y467/199) PIK3R1 Antibody

Primary Antibodies

83598 MW

WB: 1:500-1:1000
IHC: 1:50-1:200

Phosphatidylinositol 3-kinase regulatory subunit alpha

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

1 mg/ml

Binds to activated (phosphorylated) protein-Tyr kinases,
through its SH2 domain, and acts as an adapter, mediating the
association of the p110 catalytic unit to the plasma membrane.
Necessary for the insulin-stimulated increase in glucose uptake
and glycogen synthesis in insulin-sensitive tissues. Plays an
important role in signaling in response to FGFR1, FGFR2, FGFR3,
FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role
in ITGB2 signaling (PubMed:17626883, PubMed:19805105,
PubMed:7518429). Modulates the cellular response to ER stress by
promoting nuclear translocation of XBP1 isoform 2 in a ER
stress- and/or insulin-dependent manner during metabolic
overloading in the liver and hence plays a role in glucose
tolerance improvement (PubMed:20348923).

Isoform 2 is expressed in skeletal muscle and
brain, and at lower levels in kidney and cardiac muscle. Isoform 2
and isoform 4 are present in skeletal muscle (at protein level).