Anti-Mitofusin-2 MFN2 Antibody

MFN2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Polyclonal

MFN2

MFN2 antibody is human, mouse and rat reactive. At least three isoforms of MFN2 are known to exist. MFN2 antibody is predicted to not cross-react with MFN1.

MFN2 antibody was raised against a 17 amino acid peptide near the center of human MFN2. The immunogen is located within amino acids 250 - 300 of MFN2.

MFN2 antibody is affinity chromatography purified via peptide column.

Obesity, Apoptosis

Mitochondrial outer membrane GTPase that mediates
mitochondrial clustering and fusion (PubMed:11181170,
PubMed:11950885, PubMed:28114303). Mitochondria are highly dynamic
organelles, and their morphology is determined by the equilibrium
between mitochondrial fusion and fission events (PubMed:28114303).
Overexpression induces the formation of mitochondrial networks
(PubMed:28114303). Membrane clustering requires GTPase activity
and may involve a major rearrangement of the coiled coil domains
(Probable). Plays a central role in mitochondrial metabolism and
may be associated with obesity and/or apoptosis processes (By
similarity). Plays an important role in the regulation of vascular
smooth muscle cell proliferation (By similarity). Involved in the
clearance of damaged mitochondria via selective autophagy
(mitophagy) (PubMed:23620051). Is required for PRKN recruitment to
dysfunctional mitochondria (PubMed:23620051). Involved in the
control of unfolded protein response (UPR) upon ER stress
including activation of apoptosis and autophagy during ER stress
(By similarity). Acts as an upstream regulator of EIF2AK3 and
suppresses EIF2AK3 activation under basal conditions (By
similarity).

Boster Bio Anti-Mitofusin-2 MFN2 Antibody (Catalog # A00461). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

MFN2 antibody is human, mouse and rat reactive. At least three isoforms of MFN2 are known to exist. MFN2 antibody is predicted to not cross-react with MFN1.