Anti-LRP5 Antibody

Primary Antibodies

179145 MW

WB: 1:100-1:500
ICC/IF: 1:50-1:200

Low-density lipoprotein receptor-related protein 5

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

1 mg/ml

Acts as a coreceptor with members of the frizzled family
of seven-transmembrane spanning receptors to transduce signal by
Wnt proteins (PubMed:11336703, PubMed:11448771, PubMed:15778503,
PubMed:11719191, PubMed:15908424, PubMed:16252235). Activates the
canonical Wnt signaling pathway that controls cell fate
determination and self-renewal during embryonic development and
adult tissue regeneration (PubMed:11336703, PubMed:11719191). In
particular, may play an important role in the development of the
posterior patterning of the epiblast during gastrulation (By
similarity). During bone development, regulates osteoblast
proliferation and differentiation thus determining bone mass
(PubMed:11719191). Mechanistically, the formation of the signaling
complex between Wnt ligand, frizzled receptor and LRP5 coreceptor
promotes the recruitment of AXIN1 to LRP5, stabilizing beta-
catenin/CTNNB1 and activating TCF/LEF-mediated transcriptional
programs (PubMed:11336703, PubMed:25920554, PubMed:24706814,
PubMed:14731402). Acts as a coreceptor for non-Wnt proteins, such
as norrin/NDP. Binding of norrin/NDP to frizzled 4/FZD4-LRP5
receptor complex triggers beta-catenin/CTNNB1-dependent signaling
known to be required for retinal vascular development
(PubMed:27228167, PubMed:16252235). Plays a role in controlling
postnatal vascular regression in retina via macrophage-induced
endothelial cell apoptosis (By similarity).

Boster Bio Anti-LRP5 Antibody catalog # A00504. Tested in WB, ICC/IF applications. This antibody reacts with Mouse, Rat.