Anti-ULK1 (S757) Antibody

Primary Antibodies

112631 MW

WB: 1:500-1:1000

Serine/threonine-protein kinase ULK1

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

1mg/ml

Serine/threonine-protein kinase involved in autophagy in
response to starvation. Acts upstream of phosphatidylinositol 3-
kinase PIK3C3 to regulate the formation of autophagophores, the
precursors of autophagosomes. Part of regulatory feedback loops in
autophagy: acts both as a downstream effector and negative
regulator of mammalian target of rapamycin complex 1 (mTORC1) via
interaction with RPTOR. Activated via phosphorylation by AMPK and
also acts as a regulator of AMPK by mediating phosphorylation of
AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively
regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and
RPTOR; however such data need additional evidences. Plays a role
early in neuronal differentiation and is required for granule cell
axon formation. May also phosphorylate SESN2 and SQSTM1 to
regulate autophagy (PubMed:25040165).

Boster Bio Anti-ULK1 (S757) Antibody catalog # A00584S757. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.