Anti-SGK1 Antibody

SGK1 antibody can be stored at 4 °C for 3 months and -20 °C stable for one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Polyclonal

SGK1

SGK1 antibody is predicted to not cross-react with other SGK protein family members. At least five isoforms are known to exist

SGK1 antibody was raised against an 18 amino acid synthetic peptide near the carboxy terminus of human SGK1. The immunogen is located within amino acids 370 - 420 of SGK1.

SGK1 Antibody is affinity chromatography purified via peptide column.

Signal Transduction

Serine/threonine-protein kinase which is involved in the
regulation of a wide variety of ion channels, membrane
transporters, cellular enzymes, transcription factors, neuronal
excitability, cell growth, proliferation, survival, migration and
apoptosis. Plays an important role in cellular stress response.
Contributes to regulation of renal Na (+) retention, renal K (+)
elimination, salt appetite, gastric acid secretion, intestinal
Na (+)/H (+) exchange and nutrient transport, insulin-dependent salt
sensitivity of blood pressure, salt sensitivity of peripheral
glucose uptake, cardiac repolarization and memory consolidation.
Up-regulates Na (+) channels: SCNN1A/ENAC, SCN5A and ASIC1/ACCN2,
K (+) channels: KCNJ1/ROMK1, KCNA1-5, KCNQ1-5 and KCNE1, epithelial
Ca (2+) channels: TRPV5 and TRPV6, chloride channels: BSND, CLCN2
and CFTR, glutamate transporters: SLC1A3/EAAT1, SLC1A2 /EAAT2,
SLC1A1/EAAT3, SLC1A6/EAAT4 and SLC1A7/EAAT5, amino acid
transporters: SLC1A5/ASCT2, SLC38A1/SN1 and SLC6A19, creatine
transporter: SLC6A8, Na (+)/dicarboxylate cotransporter:
SLC13A2/NADC1, Na (+)-dependent phosphate cotransporter:
SLC34A2/NAPI-2B, glutamate receptor: GRIK2/GLUR6. Up-regulates
carriers: SLC9A3/NHE3, SLC12A1/NKCC2, SLC12A3/NCC, SLC5A3/SMIT,
SLC2A1/GLUT1, SLC5A1/SGLT1 and SLC15A2/PEPT2. Regulates enzymes:
GSK3A/B, PMM2 and Na (+)/K (+) ATPase, and transcription factors:
CTNNB1 and nuclear factor NF-kappa-B. Stimulates sodium transport
into epithelial cells by enhancing the stability and expression of
SCNN1A/ENAC. This is achieved by phosphorylating the NEDD4L
ubiquitin E3 ligase, promoting its interaction with 14-3-3
proteins, thereby preventing it from binding to SCNN1A/ENAC and
targeting it for degradation. Regulates store-operated Ca (+2)
entry (SOCE) by stimulating ORAI1 and STIM1. Regulates KCNJ1/ROMK1
directly via its phosphorylation or indirectly via increased
interaction with SLC9A3R2/NHERF2. Phosphorylates MDM2 and
activates MDM2-dependent ubiquitination of p53/TP53.
Phosphorylates MAPT/TAU and mediates microtubule depolymerization
and neurite formation in hippocampal neurons. Phosphorylates
SLC2A4/GLUT4 and up-regulates its activity. Phosphorylates
APBB1/FE65 and promotes its localization to the nucleus.
Phosphorylates MAPK1/ERK2 and activates it by enhancing its
interaction with MAP2K1/MEK1 and MAP2K2/MEK2. Phosphorylates FBXW7
and plays an inhibitory role in the NOTCH1 signaling.
Phosphorylates FOXO1 resulting in its relocalization from the
nucleus to the cytoplasm. Phosphorylates FOXO3, promoting its exit
from the nucleus and interference with FOXO3-dependent
transcription. Phosphorylates BRAF and MAP3K3/MEKK3 and inhibits
their activity. Phosphorylates SLC9A3/NHE3 in response to
dexamethasone, resulting in its activation and increased
localization at the cell membrane. Phosphorylates CREB1. Necessary
for vascular remodeling during angiogenesis. Sustained high levels
and activity may contribute to conditions such as hypertension and
diabetic nephropathy. Isoform 2 exhibited a greater effect on cell
plasma membrane expression of SCNN1A/ENAC and Na (+) transport than
isoform 1.

Boster Bio Anti-SGK1 Antibody (Catalog # A00673-1). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Bovine, Chicken, Rabbit