Anti-FGFR4 (phospho-Y642) Antibody

Primary Antibodies

87954 MW

WB: 1:500-1:1000

Fibroblast growth factor receptor 4

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

1 mg/ml

Tyrosine-protein kinase that acts as cell-surface
receptor for fibroblast growth factors and plays a role in the
regulation of cell proliferation, differentiation and migration,
and in regulation of lipid metabolism, bile acid biosynthesis,
glucose uptake, vitamin D metabolism and phosphate homeostasis.
Required for normal down-regulation of the expression of CYP7A1,
the rate-limiting enzyme in bile acid synthesis, in response to
FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the
activation of several signaling cascades. Activation of PLCG1
leads to the production of the cellular signaling molecules
diacylglycerol and inositol 1, 4, 5-trisphosphate. Phosphorylation
of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and
mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP
kinase signaling pathway, as well as of the AKT1 signaling
pathway. Promotes SRC-dependent phosphorylation of the matrix
protease MMP14 and its lysosomal degradation. FGFR4 signaling is
down-regulated by receptor internalization and degradation; MMP14
promotes internalization and degradation of FGFR4. Mutations that
lead to constitutive kinase activation or impair normal FGFR4
inactivation lead to aberrant signaling.

Boster Bio Anti-FGFR4 (phospho-Y642) Antibody catalog # A00769Y642. Tested in WB applications. This antibody reacts with Human.