Anti-LRP6 Antibody

Primary Antibodies

180429 MW

WB 1:500-2000
ELISA 1:5000-20000

Low-density lipoprotein receptor-related protein 6

Liquid form in PBS containing 50% glycerol, and 0.02% sodium azide.

1 mg/ml

Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers
beta-catenin signaling through inducing aggregation of receptor-
ligand complexes into ribosome-sized signalsomes. Cell-surface
coreceptor of Wnt/beta-catenin signaling, which plays a pivotal
role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor
complex recruits DVL1 polymers to the plasma membrane which, in
turn, recruits the AXIN1/GSK3B-complex to the cell surface
promoting the formation of signalsomes and inhibiting AXIN1/GSK3-
mediated phosphorylation and destruction of beta-catenin. Required
for posterior patterning of the epiblast during gastrulation (By
similarity).

Boster Bio Anti-LRP6 Antibody catalog # A00970. Tested in WB, ELISA applications. This antibody reacts with Human, Mouse.

Boster Bio Anti-LRP6 Antibody catalog # A00970. Tested in ELISA, WB applications. This antibody reacts with Human, Mouse.