Anti-CRTC2 Antibody

ArtNr	BOS-A01118
Hersteller	Boster
Menge	0.1 mg
Kategorie	Metabolism Diabetes Cholesterol & Lipid Metabolism Regulation of Appetite Immunohistochemistry Western Blot ELISA Immunofluorescence Immunostaining
Format	Liquid
Applikationen	WB, IF, ELISA, IHC-P
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Alias	TORC2,TORC-2,TORC2,CREB-regulated transcription coactivator 2,Transducer of regulated cAMP response element-binding protein 2
Lieferbar
Manufacturer - Category	Primary Antibodies
Storage Conditions	CRTC2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Molecular Weight	73302 MW
Clonality	Polyclonal
Application Details	CRTC2 antibody can be used for detection of CRTC2 by Western blot at 1 - 2 μg/mL. Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Gene Name	CRTC2
Gene Full Name	CREB regulated transcription coactivator 2
Manufacturer - Specificity	Multiple isoforms of CRTC2 are known to exist. CRTC2 antibody is predicted to not cross-react with CRTC1.
Background	CRTC2, also known as TORC2 (Transducers Of Regulated cAMP Response Element-Binding (CREB)) 2 and the related protein CRTC1 are potent CREB coactivators that are exported from the nucleus in a CRM1-dependent manner via phosphorylation-dependent interactions. Studies suggest that their phosphorylation and nuclear/cytoplasmic shuttling play an important role in the regulation of gluconeogenesis by cAMP. CRTC2 is present in both B and T-lymphocytes and abundantly expressed in the thymus. Its activity is important in regulating the expression of genes involved in cellular energy metabolism while CRTC1 is essential for energy balance and fertility.
Immunogen	CRTC2 antibody was raised against a 16 amino acid peptide near the carboxy terminus of human CRTC2. The immunogen is located within the last 50 amino acids of CRTC2.
Contents	CRTC2 Antibody is supplied in PBS containing 0.02% sodium azide.
Purification	CRTC2 Antibody is affinity chromatography purified via peptide column.
Concentration	1 mg/mL
Manufacturer - Research Category	Signal Transduction
Protein Name	CREB regulated transcription coactivator 2
Protein Function	Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).
Subcellular Localization	Cytoplasm
Description	Boster Bio Anti-CRTC2 Antibody (Catalog # A01118). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Tissue Specificity	Most abundantly expressed in the thymus. Present in both B and T-lymphocytes. Highly expressed in HEK293T cells and in insulinomas. High levels also in spleen, ovary, muscle and lung, with highest levels in muscle. Lower levels found in brain, colon, heart, kidney, prostate, small intestine and stomach. Weak expression in liver and pancreas.
Predicted Reactivity	Bovine
Manufacturer - Cross Reactivity	Multiple isoforms of CRTC2 are known to exist. CRTC2 antibody is predicted to not cross-react with CRTC1.

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BOS-A01118-datasheet.pdf

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