Anti-Zinc transporter 8 SLC30A8 Antibody

Primary Antibodies

40755 MW

SLC30A8 antibody can be used for Western blot at 1 - 2 μg/mL. Antibody can also be used for Immunohistochemistry starting at 10 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.

Solute carrier family 30 member 8

SLC30A8 is a zinc efflux transporter involved in the accumulation of zinc in intracellular vesicles and is expressed at a high level in the pancreas, particularly in islets of Langerhans, and co-localizes with insulin in the secretory pathway granules of the insulin-secreting INS-1 cells (1). Allelic variants of SLC30A8 have been identified as major genetic risk factors for the development of Type 2 diabetes (2), but no genetic association has been found with Type 1 diabetes (3). SLC30A8 expression in -cells was found to be influenced by cytokine expression, particularly IFN-gamma and IL-1beta (4).

SLC30A8 Antibody is supplied in PBS containing 0.02% sodium azide.

1 mg/mL

Solute carrier family 30 member 8

Cell membrane; Multi-pass
membrane protein. Cytoplasmic vesicle, secretory
vesicle membrane; Multi-pass membrane protein
. Associated with insulin and glucagon secretory
granules.

In the endocrine pancreas, expressed in
insulin-producing beta cells. Expressed at relatively high levels
in subcutaneous fat tissue from lean persons; much lower levels in
visceral fat, whether from lean or obese individuals, and in
subcutaneous fat tissue from obese individuals. Expressed in
peripheral blood mononuclear cells, including T-cells and B-cells,
with great variation among individuals ranging from negative to
strongly positive.