Anti-Raptor (S792) RPTOR Antibody

Primary Antibodies

149038 MW

WB: 1:500-1:1000
IHC: 1:50-1:200

Regulatory-associated protein of mTOR

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

1 mg/ml

Involved in the control of the mammalian target of
rapamycin complex 1 (mTORC1) activity which regulates cell growth
and survival, and autophagy in response to nutrient and hormonal
signals; functions as a scaffold for recruiting mTORC1 substrates.
mTORC1 is activated in response to growth factors or amino acids.
Growth factor-stimulated mTORC1 activation involves a AKT1-
mediated phosphorylation of TSC1-TSC2, which leads to the
activation of the RHEB GTPase that potently activates the protein
kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires
its relocalization to the lysosomes mediated by the Ragulator
complex and the Rag GTPases. Activated mTORC1 up-regulates protein
synthesis by phosphorylating key regulators of mRNA translation
and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and
releases it from inhibiting the elongation initiation factor 4E
(eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389',
which then promotes protein synthesis by phosphorylating PDCD4 and
targeting it for degradation. Involved in ciliogenesis.

Boster Bio Anti-Raptor (S792) RPTOR Antibody catalog # A01463S792. Tested in WB, IHC applications. This antibody reacts with Human, Mouse, Rat.