Anti-BNIP-3 (E96) Antibody

Primary Antibodies

27832 MW

IHC: 1:50-1:200

BCL2/adenovirus E1B 19 kDa protein-interacting protein 3

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

1 mg/ml

Apoptosis-inducing protein that can overcome BCL2
suppression. May play a role in repartitioning calcium between the
two major intracellular calcium stores in association with BCL2.
Involved in mitochondrial quality control via its interaction with
SPATA18/MIEAP: in response to mitochondrial damage, participates
in mitochondrial protein catabolic process (also named MALM)
leading to the degradation of damaged proteins inside
mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and
BNIP3L/NIX at the mitochondrial outer membrane regulates the
opening of a pore in the mitochondrial double membrane in order to
mediate the translocation of lysosomal proteins from the cytoplasm
to the mitochondrial matrix. Plays an important role in the
calprotectin (S100A8/A9)-induced cell death pathway.

Boster Bio Anti-BNIP-3 (E96) Antibody catalog # A01469-1. Tested in IHC applications. This antibody reacts with Human, Mouse, Rat.