Anti-Protein S100-A12 S100A12 Antibody

Primary Antibodies

10575 MW

WB: 1:500-1:2000
IHC: 1:50-1:200
ICC/IF: 1:50-1:200

Protein S100-A12

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

1 mg/ml

S100A12 is a calcium-, zinc- and copper-binding protein
which plays a prominent role in the regulation of inflammatory
processes and immune response. Its proinflammatory activity
involves recruitment of leukocytes, promotion of cytokine and
chemokine production, and regulation of leukocyte adhesion and
migration. Acts as an alarmin or a danger associated molecular
pattern (DAMP) molecule and stimulates innate immune cells via
binding to receptor for advanced glycation endproducts (AGER).
Binding to AGER activates the MAP-kinase and NF-kappa-B signaling
pathways leading to production of proinflammatory cytokines and
up-regulation of cell adhesion molecules ICAM1 and VCAM1. Acts as
a monocyte and mast cell chemoattractant. Can stimulate mast cell
degranulation and activation which generates chemokines, histamine
and cytokines inducing further leukocyte recruitment to the sites
of inflammation. Can inhibit the activity of matrix
metalloproteinases; MMP2, MMP3 and MMP9 by chelating Zn (2+) from
their active sites. Possesses filariacidal and filariastatic
activity. Calcitermin possesses antifungal activity against
C.albicans and is also active against E.coli and P.aeruginosa but
not L.monocytogenes and S.aureus.

Boster Bio Anti-Protein S100-A12 S100A12 Antibody catalog # A01478. Tested in WB, IHC, ICC/IF applications. This antibody reacts with Human, Mouse, Rat.

Protein S100-A12, CGRP, Calcium-binding protein in amniotic fluid 1, CAAF1, Calgranulin-C, CAGC, Extracellular newly identified RAGE-binding protein, EN-RAGE, Migration inhibitory factor-related protein 6, MRP-6, p6, Neutrophil S100 protein, S100 calcium-binding protein A12, Calcitermin, S100A12