Anti-Bim EL BCL2L11 Antibody

Primary Antibodies

22171 MW

Bim EL antibody can be used for detection of Bim EL by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.

BCL2-like 11 (apoptosis facilitator)

Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, and Hrk, form a growing subclass of the Bcl-2 family. Bim, also known as Bcl-2-like protein 11, is a pro-apoptotic member of this family and interacts with diverse members in the pro-survival Bcl-2 sub-family including Bcl-2, Bcl-xL and Bcl-w. Multiple isoforms of Bim are known to exist, with Bim EL being the longest isoform (1, 2).

Bim EL Antibody is supplied in PBS containing 0.02% sodium azide.

1 mg/mL

BCL2-like 11 (apoptosis facilitator)

Endomembrane system;
Peripheral membrane protein. Associated with
intracytoplasmic membranes.

Isoform BimEL, isoform BimL and isoform BimS
are the predominant isoforms and are widely expressed with tissue-
specific variation. Isoform Bim-gamma is most abundantly expressed
in small intestine and colon, and in lower levels in spleen,
prostate, testis, heart, liver and kidney.