Anti-SR-2C (Q437) HTR2C Antibody

Primary Antibodies

51821 MW

WB: 1:500-1:1000
IHC: 1:50-1:200
IF: 1:50-1:200

5-hydroxytryptamine receptor 2C

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

1 mg/ml

G-protein coupled receptor for 5-hydroxytryptamine
(serotonin). Also functions as a receptor for various drugs and
psychoactive substances, including ergot alkaloid derivatives, 1-
2, 5, -dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid
diethylamide (LSD). Ligand binding causes a conformation change
that triggers signaling via guanine nucleotide-binding proteins (G
proteins) and modulates the activity of down-stream effectors.
Beta-arrestin family members inhibit signaling via G proteins and
mediate activation of alternative signaling pathways. Signaling
activates a phosphatidylinositol-calcium second messenger system
that modulates the activity of phosphatidylinositol 3-kinase and
down-stream signaling cascades and promotes the release of Ca (2+)
ions from intracellular stores. Regulates neuronal activity via
the activation of short transient receptor potential calcium
channels in the brain, and thereby modulates the activation of
pro-opiomelacortin neurons and the release of CRH that then
regulates the release of corticosterone. Plays a role in the
regulation of appetite and eating behavior, responses to
anxiogenic stimuli and stress. Plays a role in insulin sensitivity
and glucose homeostasis.

Boster Bio Anti-SR-2C (Q437) HTR2C Antibody catalog # A01593. Tested in WB, IHC, IF applications. This antibody reacts with Human, Mouse, Rat.