Anti-Endoribonuclease ZC3H12A ZC3H12A Antibody

ZC3H12A antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Polyclonal

ZC3H12A

This ZC3H12A antibody is predicted to have no cross-reactivity to other members of the ZC3H12 protein family.

ZC3H12A antibody was raised against a 17 amino acid synthetic peptide near the center of human ZC3H12A. The immunogen is located within amino acids 330 - 380 of ZC3H12A.

ZC3H12A Antibody is affinity chromatography purified via peptide column.

Innate Immunity

Endoribonuclease involved in various biological
functions such as cellular inflammatory response and immune
homeostasis, glial differentiation of neuroprogenitor cells, cell
death of cardiomyocytes, adipogenesis and angiogenesis. Functions
as an endoribonuclease involved in mRNA decay (PubMed:19909337).
Modulates the inflammatory response by promoting the degradation
of a set of translationally active cytokine-induced inflammation-
related mRNAs, such as IL6 and IL12B, during the early phase of
inflammation (PubMed:26320658). Prevents aberrant T-cell-mediated
immune reaction by degradation of multiple mRNAs controlling T-
cell activation, such as those encoding cytokines (IL6 and IL2),
cell surface receptors (ICOS, TNFRSF4 and TNFR2) and transcription
factor (REL) (By similarity). Inhibits cooperatively with ZC3H12A
the differentiation of helper T cells Th17 in lungs. They repress
target mRNA encoding the Th17 cell-promoting factors IL6, ICOS,
REL, IRF4, NFKBID and NFKBIZ. The cooperation requires RNA-binding
by RC3H1 and the nuclease activity of ZC3H12A (By similarity).
Self regulates by destabilizing its own mRNA (By similarity).
Cleaves mRNA harboring a stem-loop (SL), often located in their
3'-UTRs, during the early phase of inflammation in a helicase
UPF1-dependent manner (PubMed:19909337, PubMed:26320658,
PubMed:26134560, PubMed:22561375). Plays a role in the inhibition
of microRNAs (miRNAs) biogenesis (PubMed:22055188). Cleaves the
terminal loop of a set of precursor miRNAs (pre-miRNAs) important
for the regulation of the inflammatory response leading to their
degradation, and thus preventing the biosynthesis of mature miRNAs
(PubMed:22055188). Plays also a role in promoting angiogenesis in
response to inflammatory cytokines by inhibiting the production of
antiangiogenic microRNAs via its anti-dicer RNase activity
(PubMed:24048733). Affects the overall ubiquitination of cellular
proteins (By similarity). Positively regulates deubiquitinase
activity promoting the cleavage at 'Lys-48'- and 'Lys-63'-linked
polyubiquitin chains on TNF receptor-associated factors (TRAFs),
preventing JNK and NF-kappa-B signaling pathway activation, and
hence negatively regulating macrophage-mediated inflammatory
response and immune homeostasis (By similarity). Induces also
deubiquitination of the transcription factor HIF1A, probably
leading to its stabilization and nuclear import, thereby
positively regulating the expression of proangiogenic HIF1A-
targeted genes (PubMed:24048733). Involved in a TANK-dependent
negative feedback response to attenuate NF-kappaB activation
through the deubiquitination of IKBKG or TRAF6 in response to
interleukin-1-beta (IL1B) stimulation or upon DNA damage
(PubMed:25861989). Prevents stress granule (SGs) formation and
promotes macrophage apoptosis under stress conditions, including
arsenite-induced oxidative stress, heat shock and energy
deprivation (By similarity). Plays a role in the regulation of
macrophage polarization; promotes IL4-induced polarization of
macrophages M1 into anti-inflammatory M2 state (By similarity).
May also act as a transcription factor that regulates the
expression of multiple genes involved in inflammatory response,
angiogenesis, adipogenesis and apoptosis (PubMed:16574901,
PubMed:18364357). Functions as a positive regulator of glial
differentiation of neuroprogenitor cells through an amyloid
precursor protein (APP)-dependent signaling pathway
(PubMed:19185603). Attenuates septic myocardial contractile
dysfunction in response to lipopolysaccharide (LPS) by reducing I-
kappa-B-kinase (IKK)-mediated NF-kappa-B activation, and hence
myocardial proinflammatory cytokine production (By similarity).

Boster Bio Anti-Endoribonuclease ZC3H12A ZC3H12A Antibody (Catalog # A01688). Tested in ELISA, WB applications. This antibody reacts with Human.

Bovine