Anti-Phospho-Desmin (S60) Antibody

Primary Antibodies

53536 MW

IHC 1:100-1:300
ELISA 1:20000
IF 1:50-200

Desmin

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

1 mg/ml

Muscle-specific type III intermediate filament essential
for proper muscular structure and function. Plays a crucial role
in maintaining the structure of sarcomeres, inter-connecting the
Z-disks and forming the myofibrils, linking them not only to the
sarcolemmal cytoskeleton, but also to the nucleus and
mitochondria, thus providing strength for the muscle fiber during
activity (PubMed:25358400). In adult striated muscle they form a
fibrous network connecting myofibrils to each other and to the
plasma membrane from the periphery of the Z-line structures
(PubMed:24200904, PubMed:25394388, PubMed:26724190). May act as a
sarcomeric microtubule-anchoring protein: specifically associates
with detyrosinated tubulin-alpha chains, leading to buckled
microtubules and mechanical resistance to contraction. Contributes
to the transcriptional regulation of the NKX2-5 gene in cardiac
progenitor cells during a short period of cardiomyogenesis and in
cardiac side population stem cells in the adult. Plays a role in
maintaining an optimal conformation of nebulette (NEB) on heart
muscle sarcomeres to bind and recruit cardiac alpha-actin (By
similarity).

Boster Bio Anti-Phospho-Desmin (S60) Antibody catalog # A01948S60. Tested in IHC, IF, ELISA applications. This antibody reacts with Human, Mouse, Rat.